Drug interactions
Promazine + Ziprasidone
Severity: Contraindicated
Promazine and Ziprasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both phenothiazine and ziprasidone antipsychotics can prolong the QT interval. Combining them raises the risk of torsades de pointes and sudden cardiac death, and ziprasidone labeling contraindicates its use with other QT-prolonging drugs.
What this interaction means in plain words
Promazine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive blockade of cardiac hERG potassium channels causing delayed repolarization.
What to do
Do not use together; use a single antipsychotic. When switching, allow the first drug to wash out and check the ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Promazine with Ziprasidone?
MediHelp rates the interaction as contraindicated. Promazine and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both phenothiazine and ziprasidone antipsychotics can prolong the QT interval. Combining them raises the risk of torsades de pointes and sudden cardiac death, and ziprasidone labeling contraindicates its use with other QT-prolonging drugs.
How serious is the interaction between Promazine and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; use a single antipsychotic. When switching, allow the first drug to wash out and check the ECG.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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