Drug interactions
Promethazine + Ropinirole
Severity: Moderate
Promethazine and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine blocks central dopamine D2 receptors and can counteract ropinirole. This may cause worsening parkinsonian symptoms or loss of control of restless legs syndrome.
What this interaction means in plain words
Promethazine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Promethazine belongs to Respiratory; Ropinirole belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at central dopamine D2 receptors.
What to do
Avoid promethazine and choose an antiemetic without central dopamine blockade, such as ondansetron or domperidone. Watch for worsening motor symptoms if the combination is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Frequently asked questions
Can I take Promethazine with Ropinirole?
MediHelp rates the interaction as moderate. Promethazine and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promethazine blocks central dopamine D2 receptors and can counteract ropinirole. This may cause worsening parkinsonian symptoms or loss of control of restless legs syndrome.
How serious is the interaction between Promethazine and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid promethazine and choose an antiemetic without central dopamine blockade, such as ondansetron or domperidone. Watch for worsening motor symptoms if the combination is used.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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