Drug interactions
Promethazine + Salmeterol
Severity: Minor
Promethazine and Salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No clear interaction exists between these drugs. Both may cause tachycardia or QT effects in susceptible patients, but this is not well documented.
What this interaction means in plain words
Promethazine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Salmeterol belongs to Respiratory.
Why it happens
No established mechanism; possible minor additive cardiac effects.
What to do
No specific action is needed. Monitor heart rate in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Promethazine with Salmeterol?
MediHelp rates the interaction as minor. Promethazine and Salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No clear interaction exists between these drugs. Both may cause tachycardia or QT effects in susceptible patients, but this is not well documented.
How serious is the interaction between Promethazine and Salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor heart rate in patients with cardiac disease.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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