Drug interactions
Promethazine + Tretinoin
Severity: Minor
Promethazine and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine is a recognized photosensitizer and systemic tretinoin can also increase sensitivity to light. Combined use may increase the risk of exaggerated sunburn-like skin reactions.
What this interaction means in plain words
Promethazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Promethazine belongs to Respiratory; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects.
What to do
Advise sun avoidance, protective clothing and broad-spectrum sunscreen during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Promethazine with Tretinoin?
MediHelp rates the interaction as minor. Promethazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine is a recognized photosensitizer and systemic tretinoin can also increase sensitivity to light. Combined use may increase the risk of exaggerated sunburn-like skin reactions.
How serious is the interaction between Promethazine and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise sun avoidance, protective clothing and broad-spectrum sunscreen during co-therapy.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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