Drug interactions
Promethazine + Zuranolone
Severity: Moderate
Promethazine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and promethazine adds sedation. Combined use increases CNS depression and psychomotor impairment.
What this interaction means in plain words
Promethazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Promethazine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation and H1 antagonism.
What to do
Consider reducing the zuranolone dose or avoiding promethazine. Counsel patients not to drive or operate machinery and monitor for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Promethazine with Zuranolone?
MediHelp rates the interaction as moderate. Promethazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and promethazine adds sedation. Combined use increases CNS depression and psychomotor impairment.
How serious is the interaction between Promethazine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the zuranolone dose or avoiding promethazine. Counsel patients not to drive or operate machinery and monitor for excess sedation.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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