Drug interactions
Propafenone + Quinacrine
Severity: Moderate
Propafenone and Quinacrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6 and raise propafenone concentrations, increasing the risk of conduction disturbances and proarrhythmia. Data are limited.
What this interaction means in plain words
Propafenone and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP2D6 inhibition by quinacrine reduces propafenone metabolism.
What to do
Monitor ECG (PR and QRS) and heart rate, and reduce the propafenone dose if conduction prolongs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Quinacrine?
MediHelp rates the interaction as moderate. Propafenone and Quinacrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinacrine may inhibit CYP2D6 and raise propafenone concentrations, increasing the risk of conduction disturbances and proarrhythmia. Data are limited.
How serious is the interaction between Propafenone and Quinacrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG (PR and QRS) and heart rate, and reduce the propafenone dose if conduction prolongs.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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