Drug interactions
Propafenone + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Propafenone and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can cause tachycardia and QT prolongation, and propafenone is proarrhythmic. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in patients with heart disease.
What this interaction means in plain words
Propafenone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proarrhythmic effects from beta-agonist stimulation and propafenone's effects on conduction and repolarization.
What to do
Monitor heart rate, rhythm and ECG in patients with structural heart disease or arrhythmia history, and keep potassium normal. Consider whether alternative bronchodilator therapy is better suited.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Propafenone and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can cause tachycardia and QT prolongation, and propafenone is proarrhythmic. Systemic exposure from inhalation is low, so the clinical risk is modest but may matter in patients with heart disease.
How serious is the interaction between Propafenone and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and ECG in patients with structural heart disease or arrhythmia history, and keep potassium normal. Consider whether alternative bronchodilator therapy is better suited.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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