Drug interactions
Propafenone + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Propafenone and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone can prolong the QRS and, to a lesser degree, the QT interval, and vilanterol as a long-acting beta-agonist can add to cardiovascular effects such as tachycardia, hypokalemia and QT prolongation. Systemic exposure from the inhaled product is low, so the clinical risk is generally modest but may matter in patients with existing arrhythmia.
What this interaction means in plain words
Propafenone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction from propafenone and beta2-agonist stimulation.
What to do
Monitor heart rate, ECG and serum potassium when starting or adjusting the combination. Use particular care in patients with structural heart disease or baseline QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Propafenone and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone can prolong the QRS and, to a lesser degree, the QT interval, and vilanterol as a long-acting beta-agonist can add to cardiovascular effects such as tachycardia, hypokalemia and QT prolongation. Systemic exposure from the inhaled product is low, so the clinical risk is generally modest but may matter in patients with existing arrhythmia.
How serious is the interaction between Propafenone and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and serum potassium when starting or adjusting the combination. Use particular care in patients with structural heart disease or baseline QT prolongation.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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