Drug interactions
Propantheline + Umeclidinium-vilanterol
Severity: Moderate
Propantheline and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Umeclidinium is an inhaled anticholinergic and propantheline is an oral antimuscarinic, so their effects add together. This can increase dry mouth, urinary retention, constipation, blurred vision and raised intraocular pressure.
What this interaction means in plain words
Propantheline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic (anticholinergic) pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, especially urinary retention and narrow-angle glaucoma symptoms. Consider an alternative to propantheline or dose reduction if effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Propantheline with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Propantheline and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Umeclidinium is an inhaled anticholinergic and propantheline is an oral antimuscarinic, so their effects add together. This can increase dry mouth, urinary retention, constipation, blurred vision and raised intraocular pressure.
How serious is the interaction between Propantheline and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially urinary retention and narrow-angle glaucoma symptoms. Consider an alternative to propantheline or dose reduction if effects develop.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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