Drug interactions
Propranolol + Spironolactone
Severity: Minor
Propranolol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-selective beta-blockers such as propranolol can slightly raise serum potassium by blocking beta2-mediated cellular uptake, and spironolactone reduces renal potassium loss. The effect is usually small but may matter in renal impairment or diabetes.
What this interaction means in plain words
Propranolol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Aldosterone antagonism combined with beta-blocker inhibition of beta2-mediated cellular potassium uptake.
What to do
Monitor serum potassium periodically, especially with renal impairment or other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propranolol and Spironolactone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Spironolactone?
MediHelp rates the interaction as minor. Propranolol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-selective beta-blockers such as propranolol can slightly raise serum potassium by blocking beta2-mediated cellular uptake, and spironolactone reduces renal potassium loss. The effect is usually small but may matter in renal impairment or diabetes.
How serious is the interaction between Propranolol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium periodically, especially with renal impairment or other potassium-raising drugs.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
