Drug interactions
Propranolol + Terazosin
Severity: Moderate
Propranolol and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs have additive hypotensive effects, and propranolol can blunt the reflex tachycardia that normally offsets alpha-blocker vasodilation. First-dose syncope and orthostatic hypotension are the main concerns.
What this interaction means in plain words
Propranolol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Terazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotension from alpha-1 blockade and nonselective beta-blockade.
What to do
Initiate terazosin at a low bedtime dose and monitor sitting and standing blood pressure during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Terazosin?
MediHelp rates the interaction as moderate. Propranolol and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs have additive hypotensive effects, and propranolol can blunt the reflex tachycardia that normally offsets alpha-blocker vasodilation. First-dose syncope and orthostatic hypotension are the main concerns.
How serious is the interaction between Propranolol and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Initiate terazosin at a low bedtime dose and monitor sitting and standing blood pressure during titration.
What other medicines interact with Terazosin?
MediHelp also lists interactions of Terazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Terazosin page.
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