Drug interactions
Propranolol + Tolmetin
Severity: Moderate
Propranolol and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin and other NSAIDs can reduce the antihypertensive effect of beta-blockers such as propranolol, particularly with sustained use. This may lead to a rise in blood pressure that needs attention.
What this interaction means in plain words
Propranolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory renal and vascular prostaglandins causes sodium and fluid retention and counteracts the beta-blocker's blood pressure effect.
What to do
Monitor blood pressure during concurrent use, especially in the first weeks. Increase antihypertensive therapy if needed or switch to a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Tolmetin?
MediHelp rates the interaction as moderate. Propranolol and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin and other NSAIDs can reduce the antihypertensive effect of beta-blockers such as propranolol, particularly with sustained use. This may lead to a rise in blood pressure that needs attention.
How serious is the interaction between Propranolol and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during concurrent use, especially in the first weeks. Increase antihypertensive therapy if needed or switch to a non-NSAID analgesic.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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