Drug interactions
Propranolol + Triamterene
Severity: Moderate
Propranolol and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers such as propranolol can raise serum potassium by blocking cellular uptake. With triamterene this increases the risk of hyperkalemia, especially in renal impairment or diabetes.
What this interaction means in plain words
Propranolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Triamterene reduces renal potassium excretion while beta-2 blockade impairs cellular potassium uptake.
What to do
Monitor serum potassium and renal function regularly during combined use. Reduce or stop triamterene if hyperkalemia emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Triamterene?
MediHelp rates the interaction as moderate. Propranolol and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers such as propranolol can raise serum potassium by blocking cellular uptake. With triamterene this increases the risk of hyperkalemia, especially in renal impairment or diabetes.
How serious is the interaction between Propranolol and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly during combined use. Reduce or stop triamterene if hyperkalemia emerges.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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