Drug interactions
Propranolol + Valsartan
Severity: Moderate
Propranolol and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination lowers blood pressure additively and may cause hypotension or dizziness. Both can also modestly raise serum potassium, and valsartan is harmful to the fetus in pregnancy.
What this interaction means in plain words
Propranolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propranolol belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with angiotensin receptor blockade reducing potassium excretion and beta-blockade impairing cellular potassium uptake.
What to do
Monitor blood pressure and serum potassium, especially in renal impairment or diabetes. Avoid in pregnancy because of valsartan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Propranolol with Valsartan?
MediHelp rates the interaction as moderate. Propranolol and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination lowers blood pressure additively and may cause hypotension or dizziness. Both can also modestly raise serum potassium, and valsartan is harmful to the fetus in pregnancy.
How serious is the interaction between Propranolol and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium, especially in renal impairment or diabetes. Avoid in pregnancy because of valsartan.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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