Drug interactions
Protriptyline + Terbinafine
Severity: Moderate
Protriptyline and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbinafine strongly inhibits CYP2D6 and can raise protriptyline concentrations. This increases the risk of anticholinergic effects, tachycardia and conduction abnormalities.
What this interaction means in plain words
Protriptyline and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Terbinafine inhibits CYP2D6-mediated metabolism of protriptyline.
What to do
Monitor for tricyclic toxicity and ECG changes, and reduce the protriptyline dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Protriptyline with Terbinafine?
MediHelp rates the interaction as moderate. Protriptyline and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbinafine strongly inhibits CYP2D6 and can raise protriptyline concentrations. This increases the risk of anticholinergic effects, tachycardia and conduction abnormalities.
How serious is the interaction between Protriptyline and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and ECG changes, and reduce the protriptyline dose if adverse effects appear.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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