Drug interactions
Protriptyline + Tolbutamide
Severity: Minor
Protriptyline and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with altered glucose control and hypoglycemia in patients on antidiabetic drugs. The effect is inconsistent and the evidence is limited.
What this interaction means in plain words
Protriptyline and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on glucose homeostasis; the mechanism is not well established.
What to do
Monitor blood glucose when protriptyline is started or stopped and adjust the tolbutamide dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Protriptyline with Tolbutamide?
MediHelp rates the interaction as minor. Protriptyline and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with altered glucose control and hypoglycemia in patients on antidiabetic drugs. The effect is inconsistent and the evidence is limited.
How serious is the interaction between Protriptyline and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when protriptyline is started or stopped and adjust the tolbutamide dose if needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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