Drug interactions
Pseudoephedrine + Terazosin
Severity: Moderate
Pseudoephedrine and Terazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine can raise blood pressure and oppose the alpha-blocking effects of terazosin on both blood pressure and urinary flow. It may also worsen urinary retention in men with BPH.
What this interaction means in plain words
Pseudoephedrine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pseudoephedrine belongs to Respiratory; Terazosin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between sympathomimetic alpha-agonism and alpha-1 receptor blockade.
What to do
Avoid oral decongestants in men with BPH or hypertension where possible; monitor blood pressure and urinary symptoms if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Terazosin
- Alfuzosin + Terazosin Major
- Amifostine + Terazosin Major
- Avanafil + Terazosin Major
- Doxazosin + Terazosin Major
- Dutasteride-tamsulosin + Terazosin Major
- Lofexidine + Terazosin Major
Frequently asked questions
Can I take Pseudoephedrine with Terazosin?
MediHelp rates the interaction as moderate. Pseudoephedrine and Terazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine can raise blood pressure and oppose the alpha-blocking effects of terazosin on both blood pressure and urinary flow. It may also worsen urinary retention in men with BPH.
How serious is the interaction between Pseudoephedrine and Terazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral decongestants in men with BPH or hypertension where possible; monitor blood pressure and urinary symptoms if used.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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