Drug interactions
Pyrazinamide + Valoctocogene roxaparvovec
Severity: Moderate
Pyrazinamide and Valoctocogene roxaparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valoctocogene roxaparvovec frequently causes raised liver enzymes, and pyrazinamide is hepatotoxic. Combined use may heighten the risk of liver injury and confound monitoring.
What this interaction means in plain words
Pyrazinamide and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pyrazinamide belongs to Anti Bacterial; Valoctocogene roxaparvovec belongs to Miscellaneous.
Why it happens
Additive hepatotoxicity.
What to do
Monitor liver enzymes closely during the combination. Consider alternatives to pyrazinamide or interrupt hepatotoxic drugs if enzymes rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyrazinamide
- Pexidartinib + Pyrazinamide Major
- Pretomanid + Pyrazinamide Major
- Isoniazid + Pyrazinamide Moderate
- Mipomersen + Pyrazinamide Moderate
- Probenecid + Pyrazinamide Moderate
- Pyrazinamide + Rifampin Moderate
Other interactions of Valoctocogene roxaparvovec
Frequently asked questions
Can I take Pyrazinamide with Valoctocogene roxaparvovec?
MediHelp rates the interaction as moderate. Pyrazinamide and Valoctocogene roxaparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valoctocogene roxaparvovec frequently causes raised liver enzymes, and pyrazinamide is hepatotoxic. Combined use may heighten the risk of liver injury and confound monitoring.
How serious is the interaction between Pyrazinamide and Valoctocogene roxaparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely during the combination. Consider alternatives to pyrazinamide or interrupt hepatotoxic drugs if enzymes rise.
What other medicines interact with Pyrazinamide?
MediHelp also lists interactions of Pyrazinamide with, for example, Pexidartinib, Pretomanid, Isoniazid. The full list is on the Pyrazinamide page.
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