Drug interactions
Pyridoxine + Vancomycin
Severity: Minor
Pyridoxine and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral vancomycin stays in the gut and could theoretically alter vitamin-producing flora, but any effect on pyridoxine status is not clinically established.
What this interaction means in plain words
Pyridoxine and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical alteration of intestinal flora; not established.
What to do
No specific action is needed; assess vitamin status only if prolonged therapy raises concern for deficiency.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Frequently asked questions
Can I take Pyridoxine with Vancomycin?
MediHelp rates the interaction as minor. Pyridoxine and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral vancomycin stays in the gut and could theoretically alter vitamin-producing flora, but any effect on pyridoxine status is not clinically established.
How serious is the interaction between Pyridoxine and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; assess vitamin status only if prolonged therapy raises concern for deficiency.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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