Drug interactions
Quazepam + Thioridazine
Severity: Moderate
Quazepam and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a benzodiazepine hypnotic and a sedating phenothiazine increases drowsiness, psychomotor impairment and the risk of falls. Respiratory depression is more likely at higher doses or in older or frail patients.
What this interaction means in plain words
Quazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression via GABA-A potentiation and histamine, alpha-adrenergic and muscarinic blockade.
What to do
Use the lowest effective doses and counsel patients about impaired driving and alcohol avoidance. Monitor sedation and respiratory status, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Quazepam with Thioridazine?
MediHelp rates the interaction as moderate. Quazepam and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a benzodiazepine hypnotic and a sedating phenothiazine increases drowsiness, psychomotor impairment and the risk of falls. Respiratory depression is more likely at higher doses or in older or frail patients.
How serious is the interaction between Quazepam and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients about impaired driving and alcohol avoidance. Monitor sedation and respiratory status, especially in the elderly.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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