Drug interactions
Quazepam + Ziprasidone
Severity: Moderate
Quazepam and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quazepam is a long-acting benzodiazepine hypnotic and ziprasidone is a sedating antipsychotic, so combined use increases drowsiness and psychomotor impairment. Risk of falls and next-day impairment is higher in older adults.
What this interaction means in plain words
Quazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A enhancement and antagonism of histamine and adrenergic receptors.
What to do
Use the lowest effective doses and monitor for oversedation, particularly in elderly patients. Warn against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Quazepam with Ziprasidone?
MediHelp rates the interaction as moderate. Quazepam and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quazepam is a long-acting benzodiazepine hypnotic and ziprasidone is a sedating antipsychotic, so combined use increases drowsiness and psychomotor impairment. Risk of falls and next-day impairment is higher in older adults.
How serious is the interaction between Quazepam and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation, particularly in elderly patients. Warn against driving or operating machinery.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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