Drug interactions
Quercetin + Topotecan
Severity: Moderate
Quercetin and Topotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quercetin, a dietary flavonoid supplement, may inhibit P-glycoprotein and BCRP and could raise topotecan exposure, particularly with oral topotecan. Higher exposure could worsen myelosuppression and gastrointestinal toxicity.
What this interaction means in plain words
Quercetin and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible inhibition of P-gp and BCRP efflux transporters, reducing topotecan efflux and increasing absorption and systemic exposure.
What to do
Advise patients to avoid quercetin supplements during topotecan therapy, especially oral topotecan. Monitor blood counts if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicated
- Amiodarone + Topotecan Major
- Cisplatin + Topotecan Major
- Cobicistat + Topotecan Major
- Cyclosporine + Topotecan Major
- Cyclosporin + Topotecan Major
Frequently asked questions
Can I take Quercetin with Topotecan?
MediHelp rates the interaction as moderate. Quercetin and Topotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quercetin, a dietary flavonoid supplement, may inhibit P-glycoprotein and BCRP and could raise topotecan exposure, particularly with oral topotecan. Higher exposure could worsen myelosuppression and gastrointestinal toxicity.
How serious is the interaction between Quercetin and Topotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid quercetin supplements during topotecan therapy, especially oral topotecan. Monitor blood counts if used.
What other medicines interact with Topotecan?
MediHelp also lists interactions of Topotecan with, for example, Adenovirus types 4 and 7 live, Amiodarone, Cisplatin. The full list is on the Topotecan page.
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