Drug interactions
Quetiapine + Romidepsin
Severity: Moderate
Quetiapine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Electrolyte disturbances, common in oncology patients, add to the risk.
What this interaction means in plain words
Quetiapine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check and correct potassium and magnesium before and during treatment. Monitor the ECG at baseline and periodically, and consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Romidepsin?
MediHelp rates the interaction as moderate. Quetiapine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Electrolyte disturbances, common in oncology patients, add to the risk.
How serious is the interaction between Quetiapine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during treatment. Monitor the ECG at baseline and periodically, and consider an alternative antipsychotic if the QTc becomes markedly prolonged.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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