Drug interactions
Quetiapine + Triclofos
Severity: Moderate
Quetiapine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic prodrug whose active metabolite, trichloroethanol, depresses the central nervous system. Combined with quetiapine, which is itself sedating, drowsiness, psychomotor impairment and next-day sedation can be amplified. Elderly or frail patients are at greater risk of falls and confusion.
What this interaction means in plain words
Quetiapine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation by trichloroethanol and histamine H1 and alpha-1 blockade by quetiapine.
What to do
Start with the lowest effective dose of triclofos and monitor for excessive sedation, especially after dose changes. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Triclofos?
MediHelp rates the interaction as moderate. Quetiapine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic prodrug whose active metabolite, trichloroethanol, depresses the central nervous system. Combined with quetiapine, which is itself sedating, drowsiness, psychomotor impairment and next-day sedation can be amplified. Elderly or frail patients are at greater risk of falls and confusion.
How serious is the interaction between Quetiapine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective dose of triclofos and monitor for excessive sedation, especially after dose changes. Advise patients to avoid driving and alcohol.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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