Drug interactions
Quetiapine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Quetiapine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine prolongs QTc and vilanterol, a long-acting beta agonist, can cause tachycardia and QT effects, so cardiovascular effects may be additive. Systemic exposure from inhalation is low, so the clinical risk is modest.
What this interaction means in plain words
Quetiapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiovascular effects.
What to do
Monitor heart rate and palpitations, and obtain an ECG in patients with cardiac risk factors or hypokalemia. Keep the inhaler at the recommended dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Quetiapine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine prolongs QTc and vilanterol, a long-acting beta agonist, can cause tachycardia and QT effects, so cardiovascular effects may be additive. Systemic exposure from inhalation is low, so the clinical risk is modest.
How serious is the interaction between Quetiapine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and palpitations, and obtain an ECG in patients with cardiac risk factors or hypokalemia. Keep the inhaler at the recommended dose.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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