Drug interactions
Quetiapine + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Quetiapine and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine prolongs QTc and vilanterol may cause tachycardia and QT effects, so cardiovascular effects may be additive. Low systemic exposure from inhalation limits the risk in most patients.
What this interaction means in plain words
Quetiapine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiovascular effects.
What to do
Monitor for palpitations and arrhythmia, and obtain an ECG in patients with cardiac risk factors or hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Quetiapine and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine prolongs QTc and vilanterol may cause tachycardia and QT effects, so cardiovascular effects may be additive. Low systemic exposure from inhalation limits the risk in most patients.
How serious is the interaction between Quetiapine and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for palpitations and arrhythmia, and obtain an ECG in patients with cardiac risk factors or hypokalemia.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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