Drug interactions
Quetiapine + Yohimbine
Severity: Moderate
Quetiapine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic activity and can cause anxiety, hypertension and tachycardia. Quetiapine blocks alpha-1 receptors and may cause hypotension and sedation, so the effects may partly oppose each other, and yohimbine may worsen agitation or psychosis. The net result is unpredictable.
What this interaction means in plain words
Quetiapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing adrenergic actions: alpha-2 antagonism by yohimbine against alpha-1 blockade and sedation from quetiapine.
What to do
Avoid yohimbine in patients with psychiatric illness treated with quetiapine where possible. If used, monitor blood pressure, heart rate and mental state.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Yohimbine?
MediHelp rates the interaction as moderate. Quetiapine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases noradrenergic activity and can cause anxiety, hypertension and tachycardia. Quetiapine blocks alpha-1 receptors and may cause hypotension and sedation, so the effects may partly oppose each other, and yohimbine may worsen agitation or psychosis. The net result is unpredictable.
How serious is the interaction between Quetiapine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbine in patients with psychiatric illness treated with quetiapine where possible. If used, monitor blood pressure, heart rate and mental state.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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