Drug interactions
Quinapril + Sulindac
Severity: Moderate
Quinapril and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
What this interaction means in plain words
Quinapril and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, counteracting ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Quinapril with Sulindac?
MediHelp rates the interaction as moderate. Quinapril and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the antihypertensive effect of ACE inhibitors and increase the risk of acute kidney injury and hyperkalemia. Risk is higher in older patients, those with volume depletion or existing renal impairment, and with concurrent diuretics.
How serious is the interaction between Quinapril and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium when starting or changing the NSAID, and keep patients hydrated. Use the lowest effective NSAID dose for the shortest time, or choose an alternative analgesic in high-risk patients.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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