Drug interactions
Quinapril + Tolazamide
Severity: Minor
Quinapril and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and have been associated with hypoglycemia in patients using sulfonylureas or insulin. The effect is usually modest.
What this interaction means in plain words
Quinapril and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Improved insulin sensitivity, possibly via increased bradykinin, adds to sulfonylurea glucose lowering.
What to do
Monitor blood glucose when quinapril is started or the dose is increased. Reduce the tolazamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Quinapril with Tolazamide?
MediHelp rates the interaction as minor. Quinapril and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors can enhance insulin sensitivity and have been associated with hypoglycemia in patients using sulfonylureas or insulin. The effect is usually modest.
How serious is the interaction between Quinapril and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when quinapril is started or the dose is increased. Reduce the tolazamide dose if hypoglycemia occurs.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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