Drug interactions
Quinapril + Tolbutamide
Severity: Minor
Quinapril and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually small.
What this interaction means in plain words
Quinapril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
ACE inhibition may improve insulin sensitivity, adding to the sulfonylurea effect.
What to do
Monitor blood glucose when starting or adjusting quinapril and reduce the tolbutamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Quinapril with Tolbutamide?
MediHelp rates the interaction as minor. Quinapril and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may improve insulin sensitivity and enhance the glucose-lowering effect of sulfonylureas, occasionally causing hypoglycemia. The effect is usually small.
How serious is the interaction between Quinapril and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting quinapril and reduce the tolbutamide dose if hypoglycemia occurs.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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