Drug interactions
Quinidine + Rapacuronium
Severity: Moderate
Quinidine and Rapacuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine has weak neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis or cause recurarization after surgery. Rapacuronium is no longer marketed.
What this interaction means in plain words
Quinidine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive neuromuscular blockade at the neuromuscular junction.
What to do
Monitor neuromuscular function with a nerve stimulator and reduce the blocker dose; ensure full recovery before extubation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Rapacuronium?
MediHelp rates the interaction as moderate. Quinidine and Rapacuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine has weak neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis or cause recurarization after surgery. Rapacuronium is no longer marketed.
How serious is the interaction between Quinidine and Rapacuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and reduce the blocker dose; ensure full recovery before extubation.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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