Drug interactions
Quinidine + Sodium lactate
Severity: Moderate
Quinidine and Sodium lactate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lactate is converted to bicarbonate and can make the urine more alkaline, which slows the renal elimination of quinidine. Plasma quinidine levels may therefore increase, with a risk of toxicity.
What this interaction means in plain words
Quinidine and Sodium lactate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Metabolic alkalinization raises urinary pH, increasing passive tubular reabsorption of quinidine.
What to do
Monitor ECG and quinidine levels when large or repeated lactate infusions are given. Adjust the quinidine dose if levels or the QT interval rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Sodium lactate?
MediHelp rates the interaction as moderate. Quinidine and Sodium lactate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lactate is converted to bicarbonate and can make the urine more alkaline, which slows the renal elimination of quinidine. Plasma quinidine levels may therefore increase, with a risk of toxicity.
How serious is the interaction between Quinidine and Sodium lactate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and quinidine levels when large or repeated lactate infusions are given. Adjust the quinidine dose if levels or the QT interval rise.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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