Drug interactions
Quinidine + Telotristat ethyl
Severity: Moderate
Quinidine and Telotristat ethyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat ethyl may induce CYP3A4 and lower systemic exposure of CYP3A4 substrates such as quinidine. Reduced quinidine levels could lead to loss of antiarrhythmic or antimalarial efficacy.
What this interaction means in plain words
Quinidine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 increases quinidine metabolism.
What to do
Monitor clinical response and quinidine concentrations, and increase the quinidine dose if efficacy is reduced; reassess the dose when telotristat is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinidine and Telotristat ethyl, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Telotristat ethyl?
MediHelp rates the interaction as moderate. Quinidine and Telotristat ethyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat ethyl may induce CYP3A4 and lower systemic exposure of CYP3A4 substrates such as quinidine. Reduced quinidine levels could lead to loss of antiarrhythmic or antimalarial efficacy.
How serious is the interaction between Quinidine and Telotristat ethyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and quinidine concentrations, and increase the quinidine dose if efficacy is reduced; reassess the dose when telotristat is stopped.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
