Drug interactions
Quinidine + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Quinidine and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine prolongs the QT interval, and vilanterol as a long-acting beta-agonist can add to cardiovascular effects including QT prolongation and hypokalemia. Together they may raise the risk of ventricular arrhythmias, including torsades de pointes.
What this interaction means in plain words
Quinidine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization, with beta-agonist-mediated hypokalemia and sympathetic stimulation adding to quinidine's potassium channel blockade.
What to do
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use. Consider an alternative to quinidine or a non-beta-agonist bronchodilator in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Quinidine and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine prolongs the QT interval, and vilanterol as a long-acting beta-agonist can add to cardiovascular effects including QT prolongation and hypokalemia. Together they may raise the risk of ventricular arrhythmias, including torsades de pointes.
How serious is the interaction between Quinidine and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium during combined use. Consider an alternative to quinidine or a non-beta-agonist bronchodilator in patients with other QT risk factors.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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