Drug interactions
Quinidine + Vincristine liposomal
Severity: Moderate
Quinidine and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein, which may increase vincristine exposure. This could heighten neurotoxicity such as neuropathy and constipation or ileus.
What this interaction means in plain words
Quinidine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux may reduce vincristine elimination and increase tissue exposure.
What to do
Monitor closely for neurotoxicity and gastrointestinal effects and consider an alternative to quinidine. Reduce or hold vincristine if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Vincristine liposomal?
MediHelp rates the interaction as moderate. Quinidine and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-glycoprotein, which may increase vincristine exposure. This could heighten neurotoxicity such as neuropathy and constipation or ileus.
How serious is the interaction between Quinidine and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neurotoxicity and gastrointestinal effects and consider an alternative to quinidine. Reduce or hold vincristine if neurotoxicity develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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