Drug interactions
Quinidine + Vorapaxar
Severity: Moderate
Quinidine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorapaxar is metabolized mainly by CYP3A4, and quinidine is a weak CYP3A4 inhibitor and P-gp inhibitor that may raise vorapaxar levels. Higher exposure can increase bleeding risk.
What this interaction means in plain words
Quinidine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and possibly P-glycoprotein reduces vorapaxar clearance.
What to do
Monitor for bleeding signs and avoid other agents that increase bleeding risk. Consider alternative antiplatelet therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Vorapaxar?
MediHelp rates the interaction as moderate. Quinidine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorapaxar is metabolized mainly by CYP3A4, and quinidine is a weak CYP3A4 inhibitor and P-gp inhibitor that may raise vorapaxar levels. Higher exposure can increase bleeding risk.
How serious is the interaction between Quinidine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and avoid other agents that increase bleeding risk. Consider alternative antiplatelet therapy if bleeding occurs.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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