Drug interactions
Quinine + Selpercatinib
Severity: Major
Quinine and Selpercatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and selpercatinib can prolong the QT interval. Taken together they may add to the risk of torsades de pointes, especially with electrolyte disturbances or existing heart disease.
What this interaction means in plain words
Quinine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Selpercatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization (hERG) effects.
What to do
Obtain a baseline ECG and check potassium, magnesium and calcium; repeat the ECG during co-therapy. Consider an alternative antimalarial if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Quinine with Selpercatinib?
MediHelp rates the interaction as major. Quinine and Selpercatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both quinine and selpercatinib can prolong the QT interval. Taken together they may add to the risk of torsades de pointes, especially with electrolyte disturbances or existing heart disease.
How serious is the interaction between Quinine and Selpercatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium, magnesium and calcium; repeat the ECG during co-therapy. Consider an alternative antimalarial if the QTc becomes markedly prolonged.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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