Drug interactions
Quinine + Sorafenib
Severity: Major
Quinine and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval and quinine adds to this effect, increasing the risk of torsades de pointes. Risk is higher with electrolyte abnormalities or bradycardia.
What this interaction means in plain words
Quinine and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation via cardiac repolarization blockade.
What to do
Avoid if possible; otherwise obtain baseline and periodic ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Quinine with Sorafenib?
MediHelp rates the interaction as major. Quinine and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sorafenib can prolong the QT interval and quinine adds to this effect, increasing the risk of torsades de pointes. Risk is higher with electrolyte abnormalities or bradycardia.
How serious is the interaction between Quinine and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain baseline and periodic ECGs and correct potassium and magnesium.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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