Drug interactions
Quinine + Sotorasib
Severity: Major
Quinine and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib induces CYP3A4 and may affect P-gp, which could lower quinine concentrations. This may reduce antimalarial efficacy.
What this interaction means in plain words
Quinine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinine belongs to Anti Parasitic; Sotorasib belongs to Oncology.
Why it happens
Sotorasib induces CYP3A4 metabolism of quinine and may alter P-gp transport.
What to do
Avoid the combination if possible and use an alternative antimalarial. If unavoidable, monitor for treatment failure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Quinine with Sotorasib?
MediHelp rates the interaction as major. Quinine and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotorasib induces CYP3A4 and may affect P-gp, which could lower quinine concentrations. This may reduce antimalarial efficacy.
How serious is the interaction between Quinine and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an alternative antimalarial. If unavoidable, monitor for treatment failure.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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