Drug interactions
Quinine + Vandetanib
Severity: Contraindicated
Quinine and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval and vandetanib carries a boxed warning for torsades de pointes. Combined use may produce life-threatening arrhythmia.
What this interaction means in plain words
Quinine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Quinine belongs to Anti Parasitic; Vandetanib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Avoid the combination and use an alternative antimalarial. If unavoidable, monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Quinine with Vandetanib?
MediHelp rates the interaction as contraindicated. Quinine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval and vandetanib carries a boxed warning for torsades de pointes. Combined use may produce life-threatening arrhythmia.
How serious is the interaction between Quinine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimalarial. If unavoidable, monitor ECG and electrolytes frequently.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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