Drug interactions
Quinupristin / dalfopristin + Saxagliptin-metformin
Severity: Minor
Quinupristin / dalfopristin and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and could raise saxagliptin levels. Saxagliptin is well tolerated at higher exposure, so the effect is likely limited.
What this interaction means in plain words
Quinupristin / dalfopristin and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces saxagliptin metabolism.
What to do
No routine dose change is needed. Monitor for adverse effects such as hypersensitivity or infection during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinupristin / dalfopristin and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Quinupristin / dalfopristin with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and could raise saxagliptin levels. Saxagliptin is well tolerated at higher exposure, so the effect is likely limited.
How serious is the interaction between Quinupristin / dalfopristin and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for adverse effects such as hypersensitivity or infection during treatment.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
