Drug interactions
Quinupristin / dalfopristin + Verapamil
Severity: Moderate
Quinupristin / dalfopristin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase verapamil concentrations. This may cause hypotension, bradycardia or AV block.
What this interaction means in plain words
Quinupristin / dalfopristin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4 metabolism of verapamil.
What to do
Monitor heart rate, ECG and blood pressure during intravenous therapy. Reduce the verapamil dose if bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Quinupristin / dalfopristin with Verapamil?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase verapamil concentrations. This may cause hypotension, bradycardia or AV block.
How serious is the interaction between Quinupristin / dalfopristin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and blood pressure during intravenous therapy. Reduce the verapamil dose if bradycardia or hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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