Drug interactions
Quinupristin / dalfopristin + Vinblastine
Severity: Moderate
Quinupristin / dalfopristin and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase vinblastine exposure. Higher levels could worsen neurotoxicity and myelosuppression.
What this interaction means in plain words
Quinupristin / dalfopristin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, reducing vinblastine metabolism.
What to do
Use an alternative antibiotic if possible. Otherwise monitor blood counts and for neurotoxicity and constipation, and reduce the vinblastine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Quinupristin / dalfopristin with Vinblastine?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase vinblastine exposure. Higher levels could worsen neurotoxicity and myelosuppression.
How serious is the interaction between Quinupristin / dalfopristin and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. Otherwise monitor blood counts and for neurotoxicity and constipation, and reduce the vinblastine dose if toxicity occurs.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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