Drug interactions
Quinupristin / dalfopristin + Ziprasidone
Severity: Moderate
Quinupristin / dalfopristin and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and could modestly raise ziprasidone concentrations. Since ziprasidone prolongs the QT interval, any increase in exposure is of potential concern, although the clinical effect is expected to be small.
What this interaction means in plain words
Quinupristin / dalfopristin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, a minor metabolic pathway of ziprasidone.
What to do
Consider an ECG if the combination is needed and correct electrolyte abnormalities. Monitor for QT-related symptoms such as palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Ziprasidone?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and could modestly raise ziprasidone concentrations. Since ziprasidone prolongs the QT interval, any increase in exposure is of potential concern, although the clinical effect is expected to be small.
How serious is the interaction between Quinupristin / dalfopristin and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG if the combination is needed and correct electrolyte abnormalities. Monitor for QT-related symptoms such as palpitations or syncope.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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