Drug interactions
Rabeprazole + Ritonavir
Severity: Minor
Rabeprazole and Ritonavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a potent CYP3A4 inhibitor and may increase rabeprazole exposure modestly. Rabeprazole has a wide safety margin and is mostly cleared non-enzymatically, so clinical consequences are unlikely.
What this interaction means in plain words
Rabeprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Ritonavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir may reduce minor oxidative metabolism of rabeprazole.
What to do
No dose adjustment is needed for rabeprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Rabeprazole with Ritonavir?
MediHelp rates the interaction as minor. Rabeprazole and Ritonavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ritonavir is a potent CYP3A4 inhibitor and may increase rabeprazole exposure modestly. Rabeprazole has a wide safety margin and is mostly cleared non-enzymatically, so clinical consequences are unlikely.
How serious is the interaction between Rabeprazole and Ritonavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed for rabeprazole.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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