Drug interactions
Rabeprazole + Sparsentan
Severity: Moderate
Rabeprazole and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan exposure may fall with acid-reducing agents because its solubility is pH dependent. The clinical effect on proteinuria reduction is uncertain.
What this interaction means in plain words
Rabeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Rabeprazole belongs to Gastrointestinal Tract; Sparsentan belongs to Genitourinary.
Why it happens
Increased gastric pH may reduce sparsentan solubility and absorption.
What to do
Monitor proteinuria and blood pressure response, and consider whether acid suppression is needed at all.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Rabeprazole with Sparsentan?
MediHelp rates the interaction as moderate. Rabeprazole and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan exposure may fall with acid-reducing agents because its solubility is pH dependent. The clinical effect on proteinuria reduction is uncertain.
How serious is the interaction between Rabeprazole and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor proteinuria and blood pressure response, and consider whether acid suppression is needed at all.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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