Drug interactions
Rabeprazole + Vitamin B12
Severity: Minor
Rabeprazole and Vitamin B12: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-term rabeprazole use suppresses gastric acid, reducing release of vitamin B12 from dietary protein. This may lower B12 status over time, especially in older patients or those with poor intake.
What this interaction means in plain words
Rabeprazole and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Vitamin B12 belongs to Gastrointestinal Tract.
Why it happens
Reduced gastric acid and pepsin activity impairs liberation of protein-bound vitamin B12 for absorption.
What to do
Monitor serum B12 in patients on prolonged rabeprazole who have risk factors or symptoms. Supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin B12
- Chloramphenicol + Vitamin B12 Moderate
- Dichlorphenamide + Vitamin B12 Moderate
- Metformin + Vitamin B12 Moderate
- Neomycin po + Vitamin B12 Moderate
- Aspirin / citric acid / sodium bicarbonate + Vitamin B12 Minor
- Aspirin + Vitamin B12 Minor
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Frequently asked questions
Can I take Rabeprazole with Vitamin B12?
MediHelp rates the interaction as minor. Rabeprazole and Vitamin B12 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-term rabeprazole use suppresses gastric acid, reducing release of vitamin B12 from dietary protein. This may lower B12 status over time, especially in older patients or those with poor intake.
How serious is the interaction between Rabeprazole and Vitamin B12?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum B12 in patients on prolonged rabeprazole who have risk factors or symptoms. Supplement if deficient.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Chloramphenicol, Dichlorphenamide, Metformin. The full list is on the Vitamin B12 page.
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