Drug interactions
Ramelteon + Remimazolam
Severity: Moderate
Ramelteon and Remimazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remimazolam is a procedural sedative benzodiazepine, and other sedative-hypnotics may increase the depth of sedation and risk of respiratory depression. Ramelteon is weakly sedating, but monitoring is still needed.
What this interaction means in plain words
Ramelteon and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Remimazolam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor vital signs and oxygen saturation continuously during sedation and recovery. Titrate remimazolam carefully to the sedation desired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ramelteon and Remimazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Remimazolam
Frequently asked questions
Can I take Ramelteon with Remimazolam?
MediHelp rates the interaction as moderate. Ramelteon and Remimazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remimazolam is a procedural sedative benzodiazepine, and other sedative-hypnotics may increase the depth of sedation and risk of respiratory depression. Ramelteon is weakly sedating, but monitoring is still needed.
How serious is the interaction between Ramelteon and Remimazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor vital signs and oxygen saturation continuously during sedation and recovery. Titrate remimazolam carefully to the sedation desired.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
