Drug interactions
Ramelteon + Scullcap
Severity: Minor
Ramelteon and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Scullcap is traditionally used as a sedative herb and may add to the drowsiness caused by ramelteon. The clinical evidence is limited.
What this interaction means in plain words
Ramelteon and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depressant effects; the herb's constituents may act on GABA receptors.
What to do
Counsel patients on possible increased drowsiness and advise against driving if impaired. Review herbal use at medication reconciliation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Scullcap?
MediHelp rates the interaction as minor. Ramelteon and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Scullcap is traditionally used as a sedative herb and may add to the drowsiness caused by ramelteon. The clinical evidence is limited.
How serious is the interaction between Ramelteon and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on possible increased drowsiness and advise against driving if impaired. Review herbal use at medication reconciliation.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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