Drug interactions
Ramelteon + Smoking
Severity: Minor
Ramelteon and Smoking: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cigarette smoking induces CYP1A2 and can reduce ramelteon exposure, possibly weakening its effect on sleep onset. The magnitude varies between individuals.
What this interaction means in plain words
Ramelteon and Smoking have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Polycyclic aromatic hydrocarbons in smoke induce CYP1A2, increasing ramelteon metabolism.
What to do
Be aware that smokers may have a weaker response to ramelteon. Reassess efficacy if the patient's smoking status changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Smoking?
MediHelp rates the interaction as minor. Ramelteon and Smoking have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cigarette smoking induces CYP1A2 and can reduce ramelteon exposure, possibly weakening its effect on sleep onset. The magnitude varies between individuals.
How serious is the interaction between Ramelteon and Smoking?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that smokers may have a weaker response to ramelteon. Reassess efficacy if the patient's smoking status changes.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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